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Publication

Hybrid Stochastic Simulation of Rule-Based Polymerization Models

Thilo Krüger; Verena Wolf
In: Eugenio Cinquemani; Alexandre Donzé (Hrsg.). Hybrid Systems Biology. International Conference on Hybrid Systems Biology (HSB-2016), 5th International Workshop, HSB 2016, October 20-21, Grenoble, France, Pages 39-53, Vol. 9957, ISBN 9783319471518, Springer International Publishing, 9/2016.

Abstract

Modeling and simulation of polymer formation is an important field of research not only in the material sciences but also in the life sciences due to the prominent role of processes such as actin filament formation and multivalent ligand-receptor interactions. While the advantages of a rule-based description of polymerizations has been successfully demonstrated, no efficient simulation of these mostly stiff processes is currently available, in particular for large system sizes.