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Clinical Decision Support for Skin Tumor Treatment: A Case-Based Reasoning Approach

Martin Kuhn; Yannik Warnecke; Daniel Preciado-Marquez; Joscha Grüger; Laura Isabell Bley; Michael Storck; Carsten Weishaupt; Ralph Bergmann; Stephan Alexander Braun
In: Isabelle Bichindaritz; Beatriz López (Hrsg.). Case-Based Reasoning Research and Development. International Conference on Case-Based Reasoning (ICCBR), 33rd International Conference on Case-Based Reasoning, located at ICCBR-2025, June 30 - July 3, Biarritz, France, Pages 407-422, ISBN 978-3-031-96559-3, Springer Nature Switzerland, 2025.

Abstract

Cancer treatment planning is a complex and individualized process due to the variability of patient-specific factors, tumor characteristics, and evolving medical standards. Predicting the next step in diagnosis or therapy remains a significant challenge, due to the high variability and limited availability of structured medical data. Clinical Decision Support Systems (CDSS) offer a promising solution, with Case-Based Reasoning (CBR) standing out for its ability to provide interpretable and transparent recommendations. Unlike black-box machine learning models, CBR leverages past cases to generate predictions by analogy, aligning with the way clinicians naturally reason. In this work, we propose a CBR-based CDSS for skin cancer treatment that integrates medical taxonomies and patient-specific clinical features to predict the next treatment step. By focusing on both technical performance and real-world application in a medical setting, this study provides insights for the deployment of CBR-based systems in medical practice.

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